Understanding Gilbert’s Syndrome: A Guide for Well-being and Balance
Hello, I want to shed some light on a lesser-known genetic condition that affects liver function and can impact how our bodies handle certain hormones, neurotransmitters, and toxins. This condition is known as Gilbert’s Syndrome.
What is Gilbert’s Syndrome?
Gilbert’s Syndrome is a genetic liver condition in which the liver produces reduced amounts of an important enzyme called UGT1A1. This enzyme plays a central role in one of the body’s main detoxification processes, known as glucuronidation. Without adequate activity of UGT1A1, the liver struggles to break down certain substances effectively. For people with Gilbert’s Syndrome, this leads to a buildup of a compound called unconjugated bilirubin, a byproduct of red blood cell breakdown, which isn’t adequately processed by the liver.
Common Symptoms of Gilbert’s Syndrome
Many people with Gilbert’s Syndrome may not even know they have it, as symptoms can vary from mild to moderate and often come and go. Here are some of the symptoms that people with Gilbert’s Syndrome may experience:
Digestive Issues: Constipation, diarrhea, bloating, and abdominal pain that seem to have no clear cause.
Mood Changes: Depression, anxiety, and a tendency toward irritability.
Energy Challenges: Fatigue, low energy, and intolerance to prolonged fasting.
Skin & Eye Changes: A yellow tint in the skin and whites of the eyes (mild jaundice) when bilirubin levels are elevated.
Gallbladder Issues: Increased risk of gallstones due to bile imbalances.
Alcohol Sensitivity: Poor tolerance to alcohol, which may worsen symptoms.
Sleep Disturbances: Difficulty falling asleep or disrupted sleep patterns.
How Does Gilbert’s Syndrome Affect the Body?
Due to impaired glucuronidation, people with Gilbert’s Syndrome have a harder time detoxifying a range of substances, including:
Hormones: Oestrogen, in particular, relies on glucuronidation for processing. When the body can’t effectively detoxify oestrogen, hormonal imbalances can arise, potentially exacerbating symptoms such as mood swings and energy dips.
Neurotransmitters: The brain chemicals dopamine, serotonin, and glutamate are metabolised through glucuronidation. People with Gilbert’s Syndrome may have fluctuations in mood, emotional reactivity, and stress resilience, as impaired detoxification can lead to imbalances in these neurotransmitters.
Medications: Some common medications—such as acetaminophen (paracetamol), ibuprofen, and certain sedatives—also depend on glucuronidation. Individuals with Gilbert’s may experience stronger side effects from these drugs, as they’re processed more slowly in the body.
Toxins and Carcinogens: Everyday exposures to environmental toxins and dietary carcinogens are also processed through this pathway. Impaired detoxification can mean these substances linger longer in the body, potentially stressing the liver and impacting overall well-being.
The Importance of Gut Health in Gilbert’s Syndrome
Elevated bilirubin levels can contribute to intestinal hyper-permeability, or what’s commonly known as “leaky gut.” This condition can lead to digestive discomfort and inflammation, as the gut lining becomes less effective at keeping toxins and irritants out of the bloodstream. Addressing gut health is often key for individuals with Gilbert’s Syndrome to help improve digestive symptoms and overall resilience.
Natural Support Strategies for Gilbert’s Syndrome
Living well with Gilbert’s Syndrome is possible with supportive lifestyle practices. Here are some natural ways to support the liver and improve overall health with Gilbert’s:
Focus on Anti-Inflammatory Foods: Foods rich in antioxidants and anti-inflammatory properties—such as berries, leafy greens, and turmeric—can help reduce liver stress and support detoxification.
Optimize Digestive Health: Since Gilbert’s can impact digestion, consider incorporating digestive aids like fiber, probiotics, and foods rich in prebiotics (such as garlic and onions) to support a healthy gut lining.
Limit Trigger Foods and Substances: Reducing the intake of alcohol, processed foods, and known irritants (like caffeine) may help alleviate symptoms. Eating smaller, more frequent meals can also help, as long fasting periods may be challenging for those with Gilbert’s.
Support the Detox Pathway: Milk thistle, dandelion root, and glutathione-boosting foods (like cruciferous vegetables) can support liver health. However, always consult a healthcare provider before adding new supplements.
Mindful Stress Management: Since mood challenges are common with Gilbert’s, incorporating stress-reducing practices like yoga, meditation, or breathing exercises can be helpful. Managing stress may support mood and digestion, creating a positive cycle for wellness.
Embracing Balance with Gilbert’s Syndrome
Understanding Gilbert’s Syndrome helps us take mindful steps to support the liver and the body’s natural detoxification processes. Remember, with the right lifestyle adjustments and awareness, you can live with vitality and balance even with this condition.
If you or someone you know is navigating Gilbert’s Syndrome, a naturopathic approach can offer personalised support, helping to address underlying factors and create an empowering, health-focused lifestyle.